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    Some Work, All Play

    Some Work, All Play

    About

    Five to ten topics, sometimes about running, with lots of love and enthusiasm and science. We dig deep into training, races, studies, pop culture, and much more! With Megan Roche, M.D. and David Roche!

    Hosted By

    David Roche and Megan Roche

    327. How to Improve Fatigue Resistance, Weekly Mileage, Aerobic v. Anaerobic Systems, and Cycling Doses of Creatine

    327. How to Improve Fatigue Resistance, Weekly Mileage, Aerobic v. Anaerobic Systems, and Cycling Doses of Creatine

    September 8, 2026
    1h 39m

    We had deep thoughts on thirst traps before this great episode! There were three main training topics that all fit together. First, we connected fatigue resistance to fueling and the central nervous system, using David’s long bike past his endurance limits as some evidence.

    Next was a new study on aerobic v. anaerobic energy contribution, finding that the 50/50 turn-point was at just 78.6 seconds. This has massive implications for how we think about training, and why athletes should rarely be pushing as hard as they can.

    Then we tied it all together with some updated thoughts on uphill treadmill running from new data. It was an upscale buffet of training talk! Like a physiological Golden Corral! 

    Other topics: Rachael Rudel’s US Championship (which happened right before we recorded), how her training works, a new segment called Comments Corner, why you need to be careful about the last song you hear before racing, wisdom on performance from Roger Federer, Curt Cignetti’s unique coaching approach, toxic running groups/friends, cycling on and off creatine, weekly mileage as a proxy for growth (or not), the perils of taking off-brand probiotics, the interaction of carbs and taper theory, and the connection between our AI discussions and doping.

    We love you all! HUZZAH!

    -David and Megan

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    328. Mysteries of Fatigue Resistance, New Science on the Lactate Shuttle, Carbs and Bone Health, and Fatigue Miles

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